HPV

CANCER AND HPV

There are over one hundred viral subtypes that differ in their DNA. Some of these subtypes like HPV 16 are associated with precancerous and cancerous lesions in different parts of the body.  Other viral types that have been associated with cancerous lesions are HPV 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68 and others. HPV has been attributed as the cause of Cervical Cancer.

HPV is also linked to vaginal, vulvar, penis, anus, mouth, among others.

HPV penetrates the nucleus of normal cells inducing malignant transformation.

Not all HPV infections will become a Cancer.  Often, HPV lesions disappear alone by the host immunologic system or the performed treatment techniques to the patient.

The subtypes 6, 11, 42, 43 and 44 are related to benign genital warts in female and male genital tract, whereas HPV 16, 18, 31, 33, 35, 39, 45, 51 , 52, 56, 58, 59 and 68 are related to female and male genital cancer and others.

Skin warts are generally associated with subtypes 2 and 7, feet warts with subtypes 1, 2, 3 and 4, flat skin warts with subtypes 3 and 10. Mouth injuries are often associated with subtypes 6, 7, 11, 13, 16, 32 and others.  Epidermodysplasia verruciformis is associated with more than 15 different subtypes.

The certain diagnose most be done by molecular biology.

Using molecular pathology techniques, the HPV test, unlike the Pap smear, allows us to have a precise diagnosis of the Human Papillomavirus. The Polymerase Chain Reaction (PCR) is a painless technique which involves the extraction of cellular material as it is done in a Pap smear but, unlike this, it has a sensitivity of 100% in the cervix. In other words, there is no possibility of false negatives if the extraction is correctly performed. This molecular biology technique, which we prefer and recommend, also gives us the possibility to find out which type of HPV the patient actually has. The importance of this lies in the fact that there are tumor viruses, in other words, viruses related to cancer such as: HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68, among others. There are other viruses related to benign warts which may result unsightly or contagious. This technique is also used in other genital areas such as the vagina, vulva, anus, penis or other parts of the body, which cannot be contagious, such as the mouth or areas of the skin near the genitals and different organs where the HPV infections are less frequent, on the other hand PCR lets us know if HPV vaccines will be preventive or not .

Another currently used technique for detection of the HPV is the “hybrid-capture” test which gives us the possibility to obtain information about the human papillomaviruses connected to genital infection or cervix cancer as well as some benign viruses related to common warts. Unlike PCR, this technique does not report on the infectious type of viruses and it is only sensitive to the most frequently found viruses.
The “hybrid-capture” detects HPV viruses which are often found in the genitals. These one are classified in: Group I: 6, 11, 42, 43, 44, 53 and 54 called “low-risk” HPV types and which are not related to cancer; and Group II viruses, also called of “high-risk”: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68 related cancer.

HPV (Human Papillomavirus), can be considered a transforming agent thus called tumoral viruses.

Tumoral viruses such as some types of HPV cause the transformation of a normal into a cancerous cell. This is a result of HPV  ability to integrate its genetic information (HPV DNA) into the nuclear DNA of the host cell. Some HPV oncoproteins play an important role in this transformation.

Consultations

"DNA test for HPV detection (PCR and Hybrid Capture.) HPV in women, HPV in man. HPV TEST, Pap smear, Colposcopy. Importance of and early diagnosis of HPV. HPV and Cancer. Treatment of HPV. Low and high grade SIL . CIN 1, CIN 2, CIN 3, in situ carcinoma and its relation with HPV. Different types of treatments for HPV leep, laser, cryosurgery, endocoagulation, interferon, podophyllotoxin, other medical HPV treatments. Relation between cervical, vaginal, vulvar, penis, anus, rectum, mouth, skin cancer and HPV. HPV in pregnanHuman Papilloma Virus or HPV is the cause of Cervical cancer in women, recommendations. HPV in the newborn child. HPV vaccine". the second in frequency after breast cancer. Human papillomavirus is also related to vaginal, vulvar, anus, rectum, penis, skin and mouth cancer, depending on the subtype of HPV that is infecting.